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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC6
All Species:
10.3
Human Site:
S108
Identified Species:
17.44
UniProt:
Q99741
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99741
NP_001245.1
560
62720
S108
Q
L
T
I
K
S
P
S
K
R
E
L
A
K
V
Chimpanzee
Pan troglodytes
XP_001170406
560
62717
S108
Q
L
T
I
K
S
P
S
K
R
E
L
A
K
V
Rhesus Macaque
Macaca mulatta
XP_001096756
559
62520
S108
Q
L
T
I
K
S
P
S
K
R
E
Q
A
K
V
Dog
Lupus familis
XP_537648
559
62507
K108
L
T
I
K
S
P
S
K
R
E
Q
A
R
A
H
Cat
Felis silvestris
Mouse
Mus musculus
O89033
562
62595
P109
E
P
T
F
K
A
S
P
P
K
E
Q
D
R
V
Rat
Rattus norvegicus
NP_001101768
561
62295
A109
E
L
A
V
K
A
S
A
P
K
E
Q
D
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519126
361
39672
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001081844
554
60731
S108
A
A
A
A
T
P
L
S
P
L
K
K
L
Q
D
Zebra Danio
Brachydanio rerio
NP_001120805
561
61262
S128
P
P
R
P
I
L
S
S
H
K
V
P
L
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648247
662
75116
K203
D
E
A
K
P
R
P
K
Q
Q
E
D
P
L
A
Honey Bee
Apis mellifera
XP_625142
549
62089
P117
K
S
F
S
L
T
S
P
S
T
P
S
T
F
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999666
582
64455
V111
E
P
C
S
P
T
K
V
K
R
S
I
L
D
D
Poplar Tree
Populus trichocarpa
XP_002299817
498
55546
V100
P
N
W
N
P
R
D
V
K
Q
V
S
V
V
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09119
513
58018
G111
L
Y
I
T
G
P
P
G
T
G
K
T
A
Q
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96
89.1
N.A.
79.5
80
N.A.
45.3
N.A.
63.7
49
N.A.
33.9
36
N.A.
40
Protein Similarity:
100
100
97.5
93.5
N.A.
87.3
88.9
N.A.
52.8
N.A.
77.5
67.3
N.A.
52.1
57.3
N.A.
58.5
P-Site Identity:
100
100
93.3
0
N.A.
26.6
26.6
N.A.
0
N.A.
6.6
6.6
N.A.
13.3
0
N.A.
13.3
P-Site Similarity:
100
100
93.3
13.3
N.A.
53.3
66.6
N.A.
0
N.A.
20
13.3
N.A.
26.6
13.3
N.A.
33.3
Percent
Protein Identity:
25.8
N.A.
N.A.
N.A.
20.1
N.A.
Protein Similarity:
46.4
N.A.
N.A.
N.A.
41.2
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
22
8
0
15
0
8
0
0
0
8
29
8
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
8
0
0
0
0
8
15
8
15
% D
% Glu:
22
8
0
0
0
0
0
0
0
8
43
0
0
0
0
% E
% Phe:
0
0
8
8
0
0
0
0
0
0
0
0
0
8
8
% F
% Gly:
0
0
0
0
8
0
0
8
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% H
% Ile:
0
0
15
22
8
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
8
0
0
15
36
0
8
15
36
22
15
8
0
22
8
% K
% Leu:
15
29
0
0
8
8
8
0
0
8
0
15
22
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
15
22
0
8
22
22
36
15
22
0
8
8
8
0
8
% P
% Gln:
22
0
0
0
0
0
0
0
8
15
8
22
0
15
0
% Q
% Arg:
0
0
8
0
0
15
0
0
8
29
0
0
8
15
0
% R
% Ser:
0
8
0
15
8
22
36
36
8
0
8
15
0
8
0
% S
% Thr:
0
8
29
8
8
15
0
0
8
8
0
8
8
0
0
% T
% Val:
0
0
0
8
0
0
0
15
0
0
15
0
8
8
36
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _